The tumor suppressor gene wwox links the canonical and non-canonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis Running title: WWOX in Tax tumorigenesis

University of Pittsburgh Cancer Institute, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan Transdisciplinary Research Organization for Subtropics and Island Studies, University of the Ryukyus, Okinawa, Japan The Lautenberg Center for General and Tumor Immunology, Institute for Medical Research IsraelCanada, Hebrew University-Hadassah Medical School, Jerusalem, Israel Child Health Institute of New Jersey, Departments of Pediatrics, Molecular Genetics, Microbiology and Immunology, UMDNJ-RWJMS, New Brunswick, NJ, USA These authors contributed equally to this work